875647-81-7
Chemical Structure
AZD-2327
- CAS No.: 875647-81-7
- Formula:C29H35FN4O
- Molecular Weight:474.61
IUPAC Name: (R)-4-((3-aminophenyl)(4-(4-fluorobenzyl)piperazin-1-yl)methyl)-N,N-diethylbenzamide
InChIKey: XGFLMBBZEPJGHY-MUUNZHRXSA-N
SMILES: CCN(CC)C(C(C=C1)=CC=C1[C@H](C2=CC(N)=CC=C2)N3CCN(CC4=CC=C(F)C=C4)CC3)=O
Biological Activity: AZD-2327 is a potent and selective δ-opioid receptor agonist. AZD-2327 binds to the human opioid receptor (Ki of 0.49 and 0.75 nM and EC50 of 24 and 9.2 nM at the C27 and F27 isoforms, respectively). AZD-2327 shows selectivity of >1000-fold over the human μ- and κ-opioid receptor subtypes as well as >130 other receptors and channels. AZD-2327 exhibits antidepressant and anxiolytic activities and can be used for the research of neurological disease[1].
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AZD-2327 | AZD-2327 is a potent and selective δ-opioid receptor agonist. AZD-2327 binds to the human opioid receptor (Ki of 0.49 and 0.75 nM and EC50 of 24 and 9.2 nM at the C27 and F27 isoforms, respectively). AZD-2327 shows selectivity of >1000-fold over the human μ- and κ-opioid receptor subtypes as well as >130 other receptors and channels. AZD-2327 exhibits antidepressant and anxiolytic activities and can be used for the research of neurological disease. | |||||||||||||||||||||
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