877606-63-8
Chemical Structure
Afacifenacin
Synonym(s): SMP-986
- CAS No.: 877606-63-8
- Formula:C27H26F3N3O2
- Molecular Weight:481.51
IUPAC Name: (S)-4-phenyl-3-(1-(3-(trifluoromethoxy)benzyl)piperidin-4-yl)-3,4-dihydroquinazolin-2(1H)-one
InChIKey: IJUMFEAYOMCXAQ-VWLOTQADSA-N
SMILES: O=C1NC2=C(C=CC=C2)[C@H](C3=CC=CC=C3)N1C4CCN(CC5=CC=CC(OC(F)(F)F)=C5)CC4
Biological Activity: Afacifenacin (SMP-986) is a potent and orally active muscarinic receptor antagonist. Afacifenacin inhibits the bladder afferent pathway through the sodium-channel blockade, increasing volume, and reducing the frequency of urination and incontinence. Afacifenacin has the potential for the research of overactive bladder (OAB)[1][2].
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Afacifenacin | Afacifenacin (SMP-986) is a potent and orally active muscarinic receptor antagonist. Afacifenacin inhibits the bladder afferent pathway through the sodium-channel blockade, increasing volume, and reducing the frequency of urination and incontinence. Afacifenacin has the potential for the research of overactive bladder (OAB). | |||||||||||||||||||||
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References
- [1]. Yeo EK, et al. New therapies in the treatment of overactive bladder. Expert Opin Emerg Drugs. 2013 Sep;18(3):319-37. [Content Brief]
- [2]. Natsuko Goto, et al. Dual inhibition of Na+-channel and muscarinic receptor by SMP-986 efficiently improved voiding function compared to anti-muscarinic agents in two conscious rat models of detrusor overactivity. The Journal of Urology. 2008, 179, 129.
