880549-30-4
Chemical Structure
Mavorixafor hydrochloride
Synonym(s): AMD-070 hydrochloride; AMD-11070 hydrochloride
- CAS No.: 880549-30-4
- Formula:C21H28ClN5
- Molecular Weight:385.93
IUPAC Name: (S)-N1-((1H-benzo[d]imidazol-2-yl)methyl)-N1-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine hydrochloride
InChIKey: DBNMEMJSDAAGNZ-FYZYNONXSA-N
SMILES: NCCCCN(CC1=NC2=CC=CC=C2N1)[C@H]3CCCC4=C3N=CC=C4.[H]Cl
Biological Activity: Mavorixafor (AMD-070) hydrochloride is a potent, selective and orally available CXCR4 antagonist, with an IC50 value of 13 nM against CXCR4 125I-SDF binding. Mavorixafor hydrochloride also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs with an IC50 of 1 nM and 9 nM, respectively. Mavorixafor hydrochloride can be used for the study of WHIM syndrome[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Mavorixafor hydrochloride | 99.64% | Mavorixafor (AMD-070) hydrochloride is a potent, selective and orally available CXCR4 antagonist, with an IC50 value of 13 nM against CXCR4 125I-SDF binding. Mavorixafor hydrochloride also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs with an IC50 of 1 nM and 9 nM, respectively. Mavorixafor hydrochloride can be used for the study of WHIM syndrome. | ||||||||||||||||||||
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