881046-01-1
881046-01-1
Chemical Structure
INI-43
- CAS No.: 881046-01-1
- Formula:C22H23N7
- Molecular Weight:385.46
IUPAC Name: 3-(1H-benzo[d]imidazol-2-yl)-1-(3-(dimethylamino)propyl)-1H-pyrrolo[2,3-b]quinoxalin-2-amine
InChIKey: LWPQQQAILAUWTI-UHFFFAOYSA-N
SMILES: NC1=C(C2=NC3=CC=CC=C3N=C2N1CCCN(C)C)C4=NC5=CC=CC=C5N4
Biological Activity: INI-43 is an inhibitor of Kpnβ1, interfering with the nuclear localization of Kpnβ1 and known Kpnβ1 cargo proteins, NFAT, NFκB, AP-1, and NFY. INI-43 can inhibit the proliferation of cancer cells, cause G2-M cell cycle arrest in cancer cells, and induce the intrinsic apoptosis pathway[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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INI-43 | 99.28% | INI-43 is an inhibitor of Kpnβ1, interfering with the nuclear localization of Kpnβ1 and known Kpnβ1 cargo proteins, NFAT, NFκB, AP-1, and NFY. INI-43 can inhibit the proliferation of cancer cells, cause G2-M cell cycle arrest in cancer cells, and induce the intrinsic apoptosis pathway. | ||||||||||||||||||||
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References
- [1]. F J Stanfield, et al. The antiviral activity of caprochlorone. Proc Soc Exp Biol Med. 1967 May;125(1):297-303. [Content Brief]
- [2]. Chi RA, et al. Inhibition of Kpnβ1 mediated nuclear import enhances cisplatin chemosensitivity in cervical cancer. BMC Cancer. 2021 Feb 2;21(1):106. [Content Brief]
- [3]. van der Watt PJ, et al. Targeting the Nuclear Import Receptor Kpnβ1 as an Anticancer Therapeutic. Mol Cancer Ther. 2016 Apr;15(4):560-73. [Content Brief]
