882757-24-6
882757-24-6
Chemical Structure
MB-07803
- CAS No.: 882757-24-6
- Formula:C24H37N4O7PS
- Molecular Weight:556.61
IUPAC Name: diethyl 2,2'-(((5-(2-amino-5-pivaloylthiazol-4-yl)furan-2-yl)phosphoryl)bis(azanediyl))bis(2-methylpropanoate)
InChIKey: CTKZZUXRWBCFEI-UHFFFAOYSA-N
SMILES: O=C(C(C)(C)NP(NC(C)(C)C(OCC)=O)(C1=CC=C(C2=C(C(C(C)(C)C)=O)SC(N)=N2)O1)=O)OCC
Biological Activity: MB-07803 is an orally active second-generation prodrug inhibitor of fructose-1,6-bisphosphatase (FBP1). MB-07803 directly inhibits the rate-limiting enzyme in gluconeogenesis. MB-07803 regulates blood glucose and is used in studies of type 2 diabetes[1][2].
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MB-07803 | MB-07803 is an orally active second-generation prodrug inhibitor of fructose-1,6-bisphosphatase (FBP1). MB-07803 directly inhibits the rate-limiting enzyme in gluconeogenesis. MB-07803 regulates blood glucose and is used in studies of type 2 diabetes. | |||||||||||||||||||||
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References
- [1]. Chen W, et al. The translational potential of miR-26 in atherosclerosis and development of agents for its target genes ACC1/2, COL1A1, CPT1A, FBP1, DGAT2, and SMAD7. Cardiovascular diabetology. 2024 Jan 09;23(1):21. [Content Brief]
- [2]. Sawant S D, et al. Comprehensive Review and Perspective on Fructose 1, 6-Bisphosphatase Inhibitors for the Management of Type 2 Diabetes Mellitus[J]. Russian Journal of Bioorganic Chemistry, 2025, 51(2): 439-464.
