885616-78-4
Chemical Structure
PI-540
- CAS No.: 885616-78-4
- Formula:C22H27N5O2S
- Molecular Weight:425.55
IUPAC Name: 3-(6-((4-methylpiperazin-1-yl)methyl)-4-morpholinothieno[3,2-d]pyrimidin-2-yl)phenol
InChIKey: OKWPNODGKOTLAT-UHFFFAOYSA-N
SMILES: OC1=CC=CC(C2=NC(N3CCOCC3)=C(SC(CN4CCN(C)CC4)=C5)C5=N2)=C1
Biological Activity: PI-540 is a bicyclic thienopyrimidine derivative and an orally active PI3K inhibitor. PI-540 has anti-cancer cell proliferation properties and high tissue distribution. PI-540 can inhibit different isoforms of PI3K, with IC50s of 10 nM (P110α), 3510 nM (P110β), 410 nM (P110δ), and 33110 nM (P110γ). PI-540 also inhibits mTOR (IC50: 61 nM) and DNA-PK (IC50: 525 nM)[1].
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PI-540 | PI-540 is a bicyclic thienopyrimidine derivative and an orally active PI3K inhibitor. PI-540 has anti-cancer cell proliferation properties and high tissue distribution. PI-540 can inhibit different isoforms of PI3K, with IC50s of 10 nM (P110α), 3510 nM (P110β), 410 nM (P110δ), and 33110 nM (P110γ). PI-540 also inhibits mTOR (IC50: 61 nM) and DNA-PK (IC50: 525 nM). | |||||||||||||||||||||
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