88598-74-7
Chemical Structure
Levomequitazine
Synonym(s): (S)-Mequitazine
- CAS No.: 88598-74-7
- Formula:C20H22N2S
- Molecular Weight:322.47
IUPAC Name: (S)-10-(quinuclidin-3-ylmethyl)-10H-phenothiazine
InChIKey: HOKDBMAJZXIPGC-INIZCTEOSA-N
SMILES: N1(C2=CC=CC=C2SC3=CC=CC=C31)C[C@H]4C5CCN(CC5)C4
Biological Activity: Levomequitazine (Compound V0114) ((S)-Mequitazine), the levorotatory enantiomer of Mequitazine (HY-B2168), is an orally active, inverse H4 receptor agonist (IC50s: 94 nM (hM2), 17 nM (hM3)). Levomequitazine strongly binds to human histamine H4 receptor. Levomequitazine antagonizes the activating action induced by histamine on H4 receptor. Levomequitazine induces a powerful and statistically significant anti-inflammatory effect. Levomequitazine can be used for research on inflammatory diseases[1].
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Levomequitazine | Levomequitazine (Compound V0114) ((S)-Mequitazine), the levorotatory enantiomer of Mequitazine (HY-B2168), is an orally active, inverse H4 receptor agonist (IC50s: 94 nM (hM2), 17 nM (hM3)). Levomequitazine strongly binds to human histamine H4 receptor. Levomequitazine antagonizes the activating action induced by histamine on H4 receptor. Levomequitazine induces a powerful and statistically significant anti-inflammatory effect. Levomequitazine can be used for research on inflammatory diseases. | |||||||||||||||||||||
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