89-68-9
Chemical Structure
Chlorothymol
Synonym(s): Chlorthymol; 6-Chlorothymol
- CAS No.: 89-68-9
- Formula:C10H13ClO
- Molecular Weight:184.67
IUPAC Name: 4-chloro-2-isopropyl-5-methylphenol
InChIKey: KFZXVMNBUMVKLN-UHFFFAOYSA-N
SMILES: CC(C1=C(O)C=C(C)C(Cl)=C1)C
Biological Activity: Chlothymol is a potent positive modulator of the GABAA receptor subunit LGC-37, anticonvulsant, and antibacterial agent. Chlothymol inhibits Pentylenetetrazol-induced c-fos expression. Chlothymol inhibits the growth of Methicillin (HY-121544)-resistant Staphylococcus aureus (MRSA) strains, including LAC, with an MIC of 32 μg/mL. Chlorothymol has protective effects against epileptic seizures in various mouse models[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Chlorothymol | 99.70% | Chlothymol is a potent positive modulator of the GABAA receptor subunit LGC-37, anticonvulsant, and antibacterial agent. Chlothymol inhibits Pentylenetetrazol-induced c-fos expression. Chlothymol inhibits the growth of Methicillin (HY-121544)-resistant Staphylococcus aureus (MRSA) strains, including LAC, with an MIC of 32 μg/mL. Chlorothymol has protective effects against epileptic seizures in various mouse models. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Alistair Jones, et al. A multiorganism pipeline for antiseizure drug discovery: Identification of chlorothymol as a novel γ-aminobutyric acidergic anticonvulsant. Epilepsia. 2020 Oct;61(10):2106-2118. [Content Brief]
- [2]. Kim BC, et al. 4-Chloro-2-Isopropyl-5-Methylphenol Exhibits Antimicrobial and Adjuvant Activity against Methicillin-Resistant Staphylococcus aureus. J Microbiol Biotechnol. 2022 Jun 28;32(6):730-739. [Content Brief]
