891849-87-9
Chemical Structure
ZK-Thiazolidinone
- CAS No.: 891849-87-9
- Formula:C23H26F3N5O2S
- Molecular Weight:493.55
IUPAC Name: (Z)-2-cyano-2-((Z)-3-ethyl-4-oxo-5-(((3-(2-(pyrrolidin-1-yl)ethyl)phenyl)amino)methylene)thiazolidin-2-ylidene)-N-(2,2,2-trifluoroethyl)acetamide
InChIKey: GPDGODLTUBVUBU-ZLHHJAJDSA-N
SMILES: N#CC(C(=O)NCC(F)(F)F)=C1SC(=CNC2=CC=CC(=C2)CCN3CCCC3)C(=O)N1CC
Biological Activity: ZK-Thiazolidinone is an ATP-competitive Polo-like kinase 1 (Plk1) inhibitor with an IC50 of 19 nM. ZK-Thiazolidinone inhibits tumor cell proliferation, induces cell cycle arrest and typical mitotic defects. ZK-Thiazolidinone impairs the recruitment of γ-tubulin and Aurora A kinase to centrosomes, resulting in failure of bipolar spindle maintenance and sister chromatid arm cohesion.\nZK-Thiazolidinone is applicable for cancer research[1].
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ZK-Thiazolidinone | ZK-Thiazolidinone is an ATP-competitive Polo-like kinase 1 (Plk1) inhibitor with an IC50 of 19 nM. ZK-Thiazolidinone inhibits tumor cell proliferation, induces cell cycle arrest and typical mitotic defects. ZK-Thiazolidinone impairs the recruitment of γ-tubulin and Aurora A kinase to centrosomes, resulting in failure of bipolar spindle maintenance and sister chromatid arm cohesion.\nZK-Thiazolidinone is applicable for cancer research. | |||||||||||||||||||||
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