895700-18-2
895700-18-2
Chemical Structure
TFCA
- CAS No.: 895700-18-2
- Formula:C18H16F3NO3
- Molecular Weight:351.32
IUPAC Name: (E)-3-(3,4-dimethoxyphenyl)-N-(4-(trifluoromethyl)phenyl)acrylamide
InChIKey: KFWWXJZNIMFFRO-ONNFQVAWSA-N
SMILES: O=C(NC1=CC=C(C(F)(F)F)C=C1)/C=C/C2=CC=C(OC)C(OC)=C2
Biological Activity: TFCA is a liver X receptor α (LXRα) antagonist. TFCA inhibits ligand-activated LXRα coactivation and transcriptional expression of the downstream target genes involved in fatty acid synthesis. TFCA attenuates ligand-induced lipogenesis and fatty liver by selectively inhibiting LXRα in the liver[1].
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TFCA | TFCA is a liver X receptor α (LXRα) antagonist. TFCA inhibits ligand-activated LXRα coactivation and transcriptional expression of the downstream target genes involved in fatty acid synthesis. TFCA attenuates ligand-induced lipogenesis and fatty liver by selectively inhibiting LXRα in the liver. | |||||||||||||||||||||
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