89595-66-4
Chemical Structure
Prunetin 5-O-β-D-glucopyranoside
- CAS No.: 89595-66-4
- Formula:C22H22O10
- Molecular Weight:446.40
IUPAC Name: 3-(4-hydroxyphenyl)-7-methoxy-5-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one
InChIKey: AJAGLPDYKVWJQE-RECXWPGBSA-N
SMILES: O=C1C(C2=CC=C(O)C=C2)=COC3=CC(OC)=CC(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O)=C13
Biological Activity: Prunetin 5-O-β-D-glucopyranoside is an isoflavone. Prunetin 5-O-β-D-glucopyranoside can be isolated from the pedicels of Prunus avium and Prunus cerasus. Prunetin 5-O-β-D-glucopyranoside acts as a non-competitive α-glucosidase inhibitor, with a IC50 of 56.05 μg/mL and a Ki of 121 μg/mL against Saccharomyces cerevisiae α-glucosidase. Prunetin 5-O-β-D-glucopyranoside can be used in studies related to type 2 diabetes[1][2].
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Prunetin 5-O-β-D-glucopyranoside | Prunetin 5-O-β-D-glucopyranoside is an isoflavone. Prunetin 5-O-β-D-glucopyranoside can be isolated from the pedicels of Prunus avium and Prunus cerasus. Prunetin 5-O-β-D-glucopyranoside acts as a non-competitive α-glucosidase inhibitor, with a IC50 of 56.05 μg/mL and a Ki of 121 μg/mL against Saccharomyces cerevisiae α-glucosidase. Prunetin 5-O-β-D-glucopyranoside can be used in studies related to type 2 diabetes. | |||||||||||||||||||||
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References
- [1]. Şöhretoğlu D, et, al. α-Glucosidase inhibitory effect of Potentilla astracanica and some isoflavones: Inhibition kinetics and mechanistic insights through in vitro and in silico studies. Int J Biol Macromol. 2017 Dec; 105(Pt 1):1062-1070. [Content Brief]
- [2]. Khalid S A, et, al. Prunetin 5-O-β-d-glucopyranoside, an isoflavone from the peduncle of Prunus avium and P. cerasus[J]. Phytochemistry, 1989, 28(5): 1560-1561.
