89781-43-1
89781-43-1
Chemical Structure
Mtb against-2
- CAS No.: 89781-43-1
- Formula:C14H16O5
- Molecular Weight:264.28
IUPAC Name: ethyl (E)-4-(3,4-dimethoxyphenyl)-4-oxobut-2-enoate
InChIKey: WXFQMQWBEXMWOA-SOFGYWHQSA-N
SMILES: C(/C=C/C(OCC)=O)(=O)C1=CC(OC)=C(OC)C=C1
Biological Activity: Mtb against-2 is an (E)-4-oxocrotonic acid derivative that acts as an inhibitor of Mycobacterium tuberculosis protein kinase B (PknB). Mtb against-2 inhibits the growth of Mycobacterium tuberculosis in vitro, with an MIC of 0.82 μg/mL against Mycobacterium tuberculosis H37Rv. Mtb against-2 can be used in tuberculosis-related research[1][2].
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Mtb against-2 | Mtb against-2 is an (E)-4-oxocrotonic acid derivative that acts as an inhibitor of Mycobacterium tuberculosis protein kinase B (PknB). Mtb against-2 inhibits the growth of Mycobacterium tuberculosis in vitro, with an MIC of 0.82 μg/mL against Mycobacterium tuberculosis H37Rv. Mtb against-2 can be used in tuberculosis-related research. | |||||||||||||||||||||
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References
- [1]. Ren J, Xu J, Zhang G, Xu C, Zhao L, You X, Wang Y, Lu Y, Yu L, Wang J. Design, synthesis, and bioevaluation of a novel class of (E)-4-oxo-crotonamide derivatives as potent antituberculosis agents. Bioorg Med Chem Lett. 2019 Feb 15;29(4):539-543.
- [2]. Xu C, Bai X, Xu J, et al. Substituted 4-oxo-crotonic acid derivatives as a new class of protein kinase B (PknB) inhibitors: synthesis and SAR study[J]. Rsc Advances, 2017, 7(8): 4763-4775.
