899452-51-8
Chemical Structure
Bis-sulfone NHS ester
- CAS No.: 899452-51-8
- Formula:C29H27NO9S2
- Molecular Weight:597.66
IUPAC Name: 2,5-dioxopyrrolidin-1-yl 4-(3-tosyl-2-(tosylmethyl)propanoyl)benzoate
InChIKey: NTRPBIATANVSPI-UHFFFAOYSA-N
SMILES: CC1=CC=C(S(=O)(CC(C(C2=CC=C(C(ON3C(CCC3=O)=O)=O)C=C2)=O)CS(=O)(C4=CC=C(C=C4)C)=O)=O)C=C1
Biological Activity: Bis-sulfone NHS Ester is a bis-alkylating labeling reagent that is selective for the cysteine sulfur atoms from a native disulfide. These reagents undergo bis-alkylation to conjugate both thiols derived from the two cysteine residues of a reduced native disulfide bond such as the interchain disulfide bonds of an antibody. The reaction results in covalent rebridging of the disulfide bond via a three carbon bridge leaving the protein structurally intact.
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Bis-sulfone NHS ester | 97.0% | Bis-sulfone NHS Ester is a bis-alkylating labeling reagent that is selective for the cysteine sulfur atoms from a native disulfide. These reagents undergo bis-alkylation to conjugate both thiols derived from the two cysteine residues of a reduced native disulfide bond such as the interchain disulfide bonds of an antibody. The reaction results in covalent rebridging of the disulfide bond via a three carbon bridge leaving the protein structurally intact. | ||||||||||||||||||||
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