89987-06-4
89987-06-4
Chemical Structure
Tiludronate
Synonym(s): Tiludronic acid
- CAS No.: 89987-06-4
- Formula:C7H9ClO6P2S
- Molecular Weight:318.61
IUPAC Name: (((4-chlorophenyl)thio)methylene)bis(phosphonic acid)
InChIKey: DKJJVAGXPKPDRL-UHFFFAOYSA-N
SMILES: O=P(O)(O)C(P(O)(O)=O)SC1=CC=C(Cl)C=C1
Biological Activity: Tiludronate (Tiludronic Acid), an orally active bisphosphonate, can act an osteoregulator. Tiludronate is used for the research of the metabolic bone disorders. Tiludronate is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase. Antiresorptive and anti-inflammatory properties[1][2][3][4].
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Tiludronate | Tiludronate (Tiludronic Acid), an orally active bisphosphonate, can act an osteoregulator. Tiludronate is used for the research of the metabolic bone disorders. Tiludronate is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase. Antiresorptive and anti-inflammatory properties. | |||||||||||||||||||||
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References
- [1]. Reginster JY, et al. Prevention of postmenopausal bone loss by tiludronate. Lancet. 1989;2(8678-8679):1469-1471. [Content Brief]
- [2]. Nunes NLT, et al. Effects of local administration of tiludronic acid on experimental periodontitis in diabetic rats. J Periodontol. 2018;89(1):105-116. [Content Brief]
- [3]. Bonjour JP, et al. Tiludronate: bone pharmacology and safety. Bone. 1995;17(5 Suppl):473S-477S. [Content Brief]
- [4]. David P, et al. The bisphosphonate tiludronate is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase. J Bone Miner Res. 1996;11(10):1498-1507. [Content Brief]
