9001-28-9
9001-28-9
Chemical Structure
Biological Activity: Canine Factor IX is a functional coagulation factor. Canine Factor IX shortens whole blood clotting time and activated partial thromboplastin time, and restores coagulation function. After intramuscular administration via rAAV vector in hemophilia B dogs, Canine Factor IX maintains a sustained circulating level for at least 1 year, partially corrects the hemophilia B phenotype in a dose-dependent manner, and its plasma expression persists for more than 17 months. Canine Factor IX is applicable to relevant research on hemophilia B[1][2].
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Canine Factor IX | Canine Factor IX is a functional coagulation factor. Canine Factor IX shortens whole blood clotting time and activated partial thromboplastin time, and restores coagulation function. After intramuscular administration via rAAV vector in hemophilia B dogs, Canine Factor IX maintains a sustained circulating level for at least 1 year, partially corrects the hemophilia B phenotype in a dose-dependent manner, and its plasma expression persists for more than 17 months. Canine Factor IX is applicable to relevant research on hemophilia B. | |||||||||||||||||||||
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Bovine Factor IX | Bovine Factor IX is prepared from freshly collected bovine plasma. Factor IX activated by the Factor VIIa/tissue factor/phospholipid complex is responsible for the activation of Factor X to Factor Xa. | |||||||||||||||||||||
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References
- [1]. Chao H, et al. Persistent expression of canine factor IX in hemophilia B canines. Gene Ther. 1999;6(10):1695-1704. [Content Brief]
- [2]. Herzog RW, et al. Long-term correction of canine hemophilia B by gene transfer of blood coagulation factor IX mediated by adeno-associated viral vector. Nat Med. 1999;5(1):56-63. [Content Brief]
