90038-01-0
90038-01-0
Chemical Structure
Detomidine hydrochloride
- CAS No.: 90038-01-0
- Formula:C12H15ClN2
- Molecular Weight:222.71
IUPAC Name: 5-(2,3-dimethylbenzyl)-1H-imidazole hydrochloride
InChIKey: OIWRDXKNDCJZSM-UHFFFAOYSA-N
SMILES: CC1=C(C)C(CC2=CN=CN2)=CC=C1.Cl
Biological Activity: Detomidine hydrochloride, an imidazole derivative, is a potent α2-adrenergic agonist. Detomidine hydrochloride produces dose-dependent analgesic effects[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Detomidine hydrochloride | 99.83% | Detomidine hydrochloride, an imidazole derivative, is a potent α2-adrenergic agonist. Detomidine hydrochloride produces dose-dependent analgesic effects. | ||||||||||||||||||||
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Detomidine hydrochloride (Standard) | 99.84% | Detomidine (hydrochloride) (Standard) is the analytical standard of Detomidine (hydrochloride). This product is intended for research and analytical applications. Detomidine hydrochloride, an imidazole derivative, is a potent α2-adrenergic agonist. Detomidine hydrochloride produces dose-dependent analgesic effects. | ||||||||||||||||||||
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Mefenidil | Mefenidil (MCN 2378) is a selective cerebral vasodilator that is not affected by beta-adrenergic blockade. Mefenidil can be used in the study of cardiovascular disease. In monkey models, mefenidil preferentially increases cerebral blood flow over systemic (femoral) blood flow. Mefenidil is also able to reduce systemic arterial pressure in anesthetized dogs. | |||||||||||||||||||||
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Immethridine dihydrobromide | 99.61% | Immethridine dihydrobromide is a selective histamine H3 receptor agonist. Immethridine dihydrobromide inhibits the expression of TLR4/CD14 and the phosphorylation of NF-κB p65. Immethridine dihydrobromide reduces inverse agonist-induced scratching, induces cheek-directed wiping rather than itching, and exerts a protective effect against HCl-induced gastric mucosal injury without affecting gastric acid secretion. Immethridine dihydrobromide attenuates experimental autoimmune encephalomyelitis and reduces inflammatory infiltration/demyelination in the spinal cord. Immethridine dihydrobromide can be used in research on autism spectrum disorders. | ||||||||||||||||||||
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FUB 349 | FUB 349 (Compound 8) is a selective Aromatase inhibitor with an IC50 of 12 μM. FUB 349 is also a H3 receptor antagonist with Kis of 12 and 2.1 nM for rH3R and hH3R, respectively. FUB 349 can be used for neurological diseases such as cognitive impairment research. | |||||||||||||||||||||
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Dexmedetomidine (Standard) | 99.92% | Dexmedetomidine (Standard) is the analytical standard of Dexmedetomidine. This product is intended for research and analytical applications. Dexmedetomidine ((+)-Medetomidine) is a potent, selective and orally active agonist of α2-adrenoceptor, with a Ki of 1.08 nM. Dexmedetomidine shows 1620-fold selectivity against α1-adrenoceptor. Dexmedetomidine exhibits anxiolysis, sedation, and modest analgesia effects. | ||||||||||||||||||||
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Levomedetomidine | Levomedetomidine is a drug impurity. | |||||||||||||||||||||
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Demiditraz | Demiditraz (PF 3814927) (example 58) is a potent parasiticide. Demiditraz shows potent anti-tick activity against Rhipicephalus sanguineus with an ED100 of 0.1 mg/cm2. Demiditraz can be used for preventing the transmission of tick-borne diseases. | |||||||||||||||||||||
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Medetomidine | 99.75% | Medetomidine is an orally active α2-adrenoceptor agonist (Ki: 1.08 nM). Medetomidine has sedative and analgesic effects. Medetomidine can cause peripheral vasoconstriction through the activation of α2 adrenoceptors on blood vessels. | ||||||||||||||||||||
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Detomidine | Detomidine, an imidazole derivative, is a potent α2-adrenergic agonist. Detomidine produces dose-dependent analgesic effects. | |||||||||||||||||||||
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2,3-Dimethylindole | 2,3-Dimethylindol is an organic liquid hydrogen carrier (LOHC). 2,3-Dimethylindol enables reversible hydrogen storage and release via catalytic hydrogenation/dehydrogenation reactions. 2,3-Dimethylindol is promising for research of clean energy storage. | |||||||||||||||||||||
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Dexmedetomidine impurity 2 | Dexmedetomidine impurity 2 is an impurity of Dexmedetomidine. | |||||||||||||||||||||
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References
- [1]. Virtanen R, et al. Pharmacological evidence for the involvement of alpha-2 adrenoceptors in the sedative effect of detomidine, a novel sedative-analgesic. J Vet Pharmacol Ther. 1985 Mar;8(1):30-7. [Content Brief]
- [2]. J Still, et al. Cardiovascular and respiratory effects of detomidine in isoflurane-anaesthetised horses. J S Afr Vet Assoc. 1996 Dec;67(4):199-203. [Content Brief]
