902128-92-1
902128-92-1
Chemical Structure
E7016
Synonym(s): GPI 21016
- CAS No.: 902128-92-1
- Formula:C20H19N3O3
- Molecular Weight:349.38
IUPAC Name: 10-((4-hydroxypiperidin-1-yl)methyl)chromeno[4,3,2-de]phthalazin-3(2H)-one
InChIKey: HAVFFEMDLROBGI-UHFFFAOYSA-N
SMILES: O=C1NN=C2C3=C1C=CC=C3OC4=CC=C(CN5CCC(O)CC5)C=C42
Biological Activity: E7016 (GPI 21016) is an orally available PARP inhibitor. E7016 can enhance tumor cell radiosensitivity in vitro and in vivo through the inhibition of DNA repair. E7016 acts as a potential anticancer agent[1][2].
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E7016 | 98.11% | E7016 (GPI 21016) is an orally available PARP inhibitor. E7016 can enhance tumor cell radiosensitivity in vitro and in vivo through the inhibition of DNA repair. E7016 acts as a potential anticancer agent. | ||||||||||||||||||||
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References
- [1]. Andrea L Russo, et al. In vitro and in vivo radiosensitization of glioblastoma cells by the poly (ADP-ribose) polymerase inhibitor E7016. Clin Cancer Res. 2009 Jan 15;15(2):607-12. [Content Brief]
- [2]. W George Lai, et al. A Baeyer-Villiger oxidation specifically catalyzed by human flavin-containing monooxygenase 5. Drug Metab Dispos. 2011 Jan;39(1):61-70. [Content Brief]
