902332-77-8
Chemical Structure
TopBP1-IN-2
- CAS No.: 902332-77-8
- Formula:C27H26N2O4
- Molecular Weight:442.51
InChIKey: REYOJBKNAKDQFQ-UHFFFAOYSA-N
SMILES: COC1=CC=CC=C1N(CC2)CCN2CC(C3=CC(O)=C(C4=CC=CC=C4)C=C3O5)=CC5=O
Biological Activity: TopBP1-IN-2 is an inhibitor of the TopBP1 BRCT7/8 domain, with a pS1159 phosphopeptide competition IC50 of 6 nM. TopBP1-IN-2 also blocks the direct interaction between TopBP1-BRCT7/8 and the DNA-binding domain of mutp53R273H, exhibiting an IC50 of 25 nM. TopBP1-IN-2 selectively induces cancer cell apoptosis and inhibits their clonogenic formation, with no significant effects on normal cells. TopBP1-IN-2 is applicable in research related to breast cancer and ovarian cancer[1].
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TopBP1-IN-2 | TopBP1-IN-2 is an inhibitor of the TopBP1 BRCT7/8 domain, with a pS1159 phosphopeptide competition IC50 of 6 nM. TopBP1-IN-2 also blocks the direct interaction between TopBP1-BRCT7/8 and the DNA-binding domain of mutp53R273H, exhibiting an IC50 of 25 nM. TopBP1-IN-2 selectively induces cancer cell apoptosis and inhibits their clonogenic formation, with no significant effects on normal cells. TopBP1-IN-2 is applicable in research related to breast cancer and ovarian cancer. | |||||||||||||||||||||
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