9025-43-8
9025-43-8
Chemical Structure
Biological Activity: β-Mannosidase is a lysosomal exo‑acting enzyme. β-Mannosidase catalyzes hydrolysis of β‑1,4‑linked mannosides, non‑reducing terminal mannoses in N‑glycoproteins, and Man‑β‑1,4‑GlcNAc linkages to release mannose. β-Mannosidase contributes to glycoprotein catabolism and supports Bifidobacteria colonization via N‑glycan depolymerization. β-Mannosidase can be used for the research of β-mannosidosis and β-mannosidase deficiency[1][2][3][4].
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β-Mannosidase | β-Mannosidase is a lysosomal exo‑acting enzyme. β-Mannosidase catalyzes hydrolysis of β‑1,4‑linked mannosides, non‑reducing terminal mannoses in N‑glycoproteins, and Man‑β‑1,4‑GlcNAc linkages to release mannose. β-Mannosidase contributes to glycoprotein catabolism and supports Bifidobacteria colonization via N‑glycan depolymerization. β-Mannosidase can be used for the research of β-mannosidosis and β-mannosidase deficiency. | |||||||||||||||||||||
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References
- [1]. Robescu MS. β-Mannosidase from Cellulomonas fimi: Immobilization Study and Application in the β-Mannoside Synthesis. Catalysts. 2023;13(11):1399.
- [2]. Gytz H, et al. The structure of mammalian β-mannosidase provides insight into β-mannosidosis and nystagmus. FEBS J. 2019;286(7):1319-1331. [Content Brief]
- [3]. Cooper A, Sardharwalla IB, Roberts MM. Human beta-mannosidase deficiency. N Engl J Med. 1986 Nov 6;315(19):1231. [Content Brief]
- [4]. Cordeiro RL, et al. N-glycan Utilization by Bifidobacterium Gut Symbionts Involves a Specialist β-Mannosidase. J Mol Biol. 2019 Feb 15;431(4):732-747. [Content Brief]
