902589-96-2
902589-96-2
Chemical Structure
YMU1
- CAS No.: 902589-96-2
- Formula:C17H22N4O4S
- Molecular Weight:378.45
IUPAC Name: ethyl 4-(2-(4,6-dimethyl-3-oxoisothiazolo[5,4-b]pyridin-2(3H)-yl)acetyl)piperazine-1-carboxylate
InChIKey: XXUFNNVFZFVKGP-UHFFFAOYSA-N
SMILES: O=C(N1CCN(C(CN2SC3=NC(C)=CC(C)=C3C2=O)=O)CC1)OCC
Biological Activity: YMU1 is a selective inhibitor of human thymidylate kinase (hTMPK) with an IC50 of 610 nM. YMU1 inhibits tumor proliferation[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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YMU1 | 99.19% | YMU1 is a selective inhibitor of human thymidylate kinase (hTMPK) with an IC50 of 610 nM. YMU1 inhibits tumor proliferation. | ||||||||||||||||||||
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References
- [1]. Hu CM, et al. Tumor cells require thymidylate kinase to prevent dUTP incorporation during DNA repair. Cancer Cell. 2012 Jul 10;22(1):36-50. [Content Brief]
- [2]. Fengqiang Yu, et al. Knockdown of DTYMK suppresses progression and EMT of lung adenocarcinoma 1 via STAT3 signaling. Europe PMC. 20 Mar 2023, 55(5):213-221.
