902614-04-4
Chemical Structure
Pantothenate kinase-IN-2
- CAS No.: 902614-04-4
- Formula:C21H21N5OS
- Molecular Weight:391.49
IUPAC Name: 3-(2,4-dimethylpyrido[2',3':3,4]pyrazolo[1,5-a]pyrimidin-3-yl)-N-(3-(methylthio)phenyl)propanamide
InChIKey: UNCZUEUPSJKHGB-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=CC(SC)=C1)CCC2=C(C)N3C(N=C2C)=C(C=CC=N4)C4=N3
Biological Activity: Pantothenate kinase-IN-2 is a pantothenate kinase inhibitor with IC50 values of 92 nM for PanK2, 70 nM for PanK1β, and 25 nM for PanK3. Pantothenate kinase-IN-2 can bind specifically to the ATP-PanK3 complex and block CoA biosynthesis. Pantothenate kinase-IN-2 can be used for the research of pank-associated neurodegeneration and type 2 diabetes[1].
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Pantothenate kinase-IN-2 | 98.18% | Pantothenate kinase-IN-2 is a pantothenate kinase inhibitor with IC50 values of 92 nM for PanK2, 70 nM for PanK1β, and 25 nM for PanK3. Pantothenate kinase-IN-2 can bind specifically to the ATP-PanK3 complex and block CoA biosynthesis. Pantothenate kinase-IN-2 can be used for the research of pank-associated neurodegeneration and type 2 diabetes. | ||||||||||||||||||||
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