903886-95-3
903886-95-3
Chemical Structure
A-908292
- CAS No.: 903886-95-3
- Formula:C18H20N2O4S
- Molecular Weight:360.43
IUPAC Name: methyl (S)-(4-(2-(4-isopropoxyphenoxy)thiazol-5-yl)but-3-yn-2-yl)carbamate
InChIKey: OLMPAYQFDVALIH-ZDUSSCGKSA-N
SMILES: COC(N[C@@H](C)C#CC1=CN=C(S1)OC2=CC=C(C=C2)OC(C)C)=O
Biological Activity: A-908292 is a potent and selective acetyl-CoA carboxylase 2 (ACC2) inhibitor, with an IC50 of 23 nM for human ACC2. A-908292 can be used for the research of fatty acid metabolism[1][2]. A-908292 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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A-908292 | 99.88% | A-908292 is a potent and selective acetyl-CoA carboxylase 2 (ACC2) inhibitor, with an IC50 of 23 nM for human ACC2. A-908292 can be used for the research of fatty acid metabolism. A-908292 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | ||||||||||||||||||||
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References
- [1]. Nishiura Y, et, al. Discovery of a novel olefin derivative as a highly potent and selective acetyl-CoA carboxylase 2 inhibitor with in vivo efficacy. Bioorg Med Chem Lett. 2018 Aug 1;28(14):2498-2503. [Content Brief]
- [2]. Waring JF, et, al. Gene expression analysis in rats treated with experimental acetyl-coenzyme A carboxylase inhibitors suggests interactions with the peroxisome proliferator-activated receptor alpha pathway. J Pharmacol Exp Ther. 2008 Feb;324(2):507-16. [Content Brief]
