903899-13-8
903899-13-8
Chemical Structure
6-Hydroxypyridin-3-ylboronic acid
- CAS No.: 903899-13-8
- Formula:C5H6BNO3
- Molecular Weight:138.92
IUPAC Name: (6-oxo-1,6-dihydropyridin-3-yl)boronic acid
InChIKey: YUOLAYZNDYRBEZ-UHFFFAOYSA-N
SMILES: OB(C1=CC=C(O)N=C1)O
Biological Activity: 6-Hydroxypyridin-3-ylboronic acid is a heterocyclic building block, which can be used in the synthesis of non-nucleoside inhibitors of hepatitis C virus (HCV) RNA-dependent RNA polymerase nonstructural protein 5B (NS5B). 6-Hydroxypyridin-3-ylboronic acid has also been used in the synthesis of mammalian target of rapamycin (mTOR) inhibitors[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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6-Hydroxypyridin-3-ylboronic acid | 6-Hydroxypyridin-3-ylboronic acid is a heterocyclic building block, which can be used in the synthesis of non-nucleoside inhibitors of hepatitis C virus (HCV) RNA-dependent RNA polymerase nonstructural protein 5B (NS5B). 6-Hydroxypyridin-3-ylboronic acid has also been used in the synthesis of mammalian target of rapamycin (mTOR) inhibitors. | |||||||||||||||||||||
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2-Fluoropyridine-4-boronic acid | 99.78% | 2-Fluoropyridine-4-boronic acid is a coupling reagent and chemical intermediate. 2-Fluoropyridine-4-boronic acid facilitates the synthesis of Rho kinase (ROCK) inhibitor Compound 37. | ||||||||||||||||||||
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2-Fluoropyridine-5-boronic acid | 99.95% | 2-Fluoropyridine-5-boronic acid (6-Fluoropyridine-3-boronic acid) is a fatty acid amide hydrolase (FAAH) inhibitor with an IC50 of 10 μM. 2-Fluoropyridine-5-boronic acid is applicable to research related to inflammation and pain. | ||||||||||||||||||||
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2-Chloropyridine-4-boronic acid | 98.25% | 2-Chloropyridine-4-boronic acid is an intermediate. 2-Chloropyridine-4-boronic acid can be used in the synthesis of nAChR agonists. 2-Chloropyridine-4-boronic acid can be used in cancer research. | ||||||||||||||||||||
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2-Chloropyridine-5-boronic acid | 99.77% | 2-Chloropyridine-5-boronic acid is a mandelate racemase (MR) inhibitor with a Ki value of 8.5 μM against Pseudomonas putida MR. | ||||||||||||||||||||
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2-Methoxypyridine-5-boronic acid | 99.84% | 2-Methoxypyridine-5-boronic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||||||||||||||||||||
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Pyridin-3-ylboronic acid | 98.48% | Pyridin-3-ylboronic acid is a synthetic building block belonging to the pyridine boronic acid class. Pyridin-3-ylboronic acid serves as a substrate for the Suzuki-Miyaura coupling reaction to construct oligopyridine backbones. Pyridin-3-ylboronic acid also acts as a heteroaryl boronic acid in the phosphine-free Suzuki-Miyaura coupling reaction of 2-iodogalactal. Pyridin-3-ylboronic acid is applicable to research related to organic synthesis. | ||||||||||||||||||||
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2-Hydroxyphenylboronic acid | 99.11% | 2-Hydroxyphenylboronic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||||||||||||||||||||
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(3-Hydroxyphenyl)boronic acid | 99.90% | (3-Hydroxyphenyl)boronic acid (3-Hydroxybenzeneboronic acid) is a drug intermediate that can be used for the synthesis of 17β-hydroxysteroid dehydrogenase type 1 inhibitors. | ||||||||||||||||||||
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6-Aminopyridine-3-boronic acid | 6-Aminopyridine-3-boronic acid is a boronic acid derivative. Boronic acid derivatives are widely used in organic synthesis for carbon-carbon bond formation. In Suzuki coupling, aryl halides and boronic acid aryl or vinyl esters or boronic acid are coupled using Pd(PPh3)4. It can be used as a pharmaceutical intermediate. | |||||||||||||||||||||
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BPBA | 99.85% | BPBA (2-Bromopyridine-5-boronic acid) is a derivatization reagent derived from Boric acid (HY-Y0314) with enhanced ionization efficiency in positive-mode electrospray ionization mass spectrometry. BPBA forms boronate ester derivatives with vicinal diols. It enables rapid, catalyst-free labeling operations, improves the detection sensitivity of liquid chromatography/mass spectrometry, and reduces false positive errors. | ||||||||||||||||||||
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References
- [1]. Hendricks RT, et al. 3-Hydroxyisoquinolines as inhibitors of HCV NS5b RNA-dependent RNA polymerase. Bioorg Med Chem Lett. 2009 Jan 15;19(2):410-4. [Content Brief]
- [2]. Verheijen JC, et al. Discovery of 4-morpholino-6-aryl-1H-pyrazolo[3,4-d]pyrimidines as highly potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR): optimization of the 6-aryl substituent. J Med Chem. 2009 Dec 24;52(24):8010-24. [Content Brief]
