9064-91-9
Chemical Structure
DEAE-dextran, MW 500000 hydrochloride
Synonym(s): DEAE-dextran, MW 500000 hydrochloride, from bacterial (Leuconostoc mesenteroides); Diethylaminoethyl-dextran, MW 500000 hydrochloride
- CAS No.: 9064-91-9
- Formula:N/A
- Molecular Weight:500000 (Average)
SMILES: [DEAE-dextran, MW 500000 (hydrochloride)]
Biological Activity: DEAE-dextran, MW 500000 hydrochloride (DEAE-dextran, MW 500000 hydrochloride, from bacterial (Leuconostoc mesenteroides)) is a high-molecular-weight positively charged polymer that significantly enhances the uptake of viral RNA by tissue culture cells. When employed in the delivery system for "tumor immunity" RNA-splenocyte transfer, DEAE-dextran can markedly extend the lifespan of tumor-bearing animals, comparable to that of actively immunized animals. Furthermore, DEAE-dextran serves as a complexing agent for nucleic acids, forming composite particles with DNA/RNA for extensive applications in gene delivery. Additionally, DEAE-dextran can be utilized as a coating for liposomes[1][2].
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DEAE-dextran, MW 500000 hydrochloride | DEAE-dextran, MW 500000 hydrochloride (DEAE-dextran, MW 500000 hydrochloride, from bacterial (Leuconostoc mesenteroides)) is a high-molecular-weight positively charged polymer that significantly enhances the uptake of viral RNA by tissue culture cells. When employed in the delivery system for "tumor immunity" RNA-splenocyte transfer, DEAE-dextran can markedly extend the lifespan of tumor-bearing animals, comparable to that of actively immunized animals. Furthermore, DEAE-dextran serves as a complexing agent for nucleic acids, forming composite particles with DNA/RNA for extensive applications in gene delivery. Additionally, DEAE-dextran can be utilized as a coating for liposomes. | |||||||||||||||||||||
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References
- [1]. Rigby P G. Prolongation of survival of tumour-bearing animals by transfer of “immune” RNA with DEAE dextran[J]. Nature, 1969, 221(5184): 968-969. [Content Brief]
- [2]. Siewert C, et al. Investigation of charge ratio variation in mRNA–DEAE-dextran polyplex delivery systems[J]. Biomaterials, 2019, 192: 612-620. [Content Brief]
