906673-33-4
906673-33-4
Chemical Structure
AN-2898
- CAS No.: 906673-33-4
- Formula:C15H9BN2O3
- Molecular Weight:276.05
IUPAC Name: 4-((1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)oxy)phthalonitrile
InChIKey: UBMGTTRDNUKZMT-UHFFFAOYSA-N
SMILES: N#CC1=CC=C(OC2=CC=C(B(O)OC3)C3=C2)C=C1C#N
Biological Activity: AN-2898 is a selective PDE4 inhibitor with IC50 of 0.027 μM over other phosphodiesterase enzymes, such as PDE1A, PDE2A and PDE3A. AN-2898 also potently inhibits PDE4 subtypes (PDE4B1, PDE4A1A and PDE4D2). AN-2898 significantly inhibits the production of TNF-α, IL-2, IFN-γ, IL-5 and IL-10. AN-2898 can be used for mild to moderate atopic dermatitis (AD) and psoriasis research[1].
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AN-2898 | AN-2898 is a selective PDE4 inhibitor with IC50 of 0.027 μM over other phosphodiesterase enzymes, such as PDE1A, PDE2A and PDE3A. AN-2898 also potently inhibits PDE4 subtypes (PDE4B1, PDE4A1A and PDE4D2). AN-2898 significantly inhibits the production of TNF-α, IL-2, IFN-γ, IL-5 and IL-10. AN-2898 can be used for mild to moderate atopic dermatitis (AD) and psoriasis research. | |||||||||||||||||||||
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