909-39-7
909-39-7
Chemical Structure
Opipramol dihydrochloride
Synonym(s): Ensidon dihydrochloride; G-33040 dihydrochloride
- CAS No.: 909-39-7
- Formula:C23H31Cl2N3O
- Molecular Weight:436.42
IUPAC Name: 2-(4-(3-(5H-dibenzo[b,f]azepin-5-yl)propyl)piperazin-1-yl)ethan-1-ol dihydrochloride
InChIKey: DLTOEESOSYKJBK-UHFFFAOYSA-N
SMILES: OCCN1CCN(CCCN2C3=CC=CC=C3C=CC4=CC=CC=C42)CC1.Cl.Cl
Biological Activity: Opipramol (Ensidon) is an atypical tricyclic antidepressant (TCA). Opipramol acts primarily as a sigma (σ) receptor agonist and can potently interact with sigma recognition sites with a Ki value of 50 nM. Opipramol can be used for the research of generalized anxiety disorder (GAD)[1][2].
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Opipramol dihydrochloride | Opipramol (Ensidon) is an atypical tricyclic antidepressant (TCA). Opipramol acts primarily as a sigma (σ) receptor agonist and can potently interact with sigma recognition sites with a Ki value of 50 nM. Opipramol can be used for the research of generalized anxiety disorder (GAD). | |||||||||||||||||||||
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References
- [1]. Möller HJ, et al. Opipramol for the treatment of generalized anxiety disorder: a placebo-controlled trial including an alprazolam-treated group. J Clin Psychopharmacol. 2001 Feb;21(1):59-65. [Content Brief]
- [2]. Rao TS, et al. Neurochemical characterization of dopaminergic effects of opipramol, a potent sigma receptor ligand, in vivo. Neuropharmacology. 1990 Dec;29(12):1191-7. [Content Brief]
