910045-32-8
910045-32-8
Chemical Structure
PQ-69
- CAS No.: 910045-32-8
- Formula:C20H19FN4O
- Molecular Weight:350.39
IUPAC Name: 4-(butylamino)-2-(3-fluorophenyl)-1,2-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one
InChIKey: FJRYQRBEISYVBB-UHFFFAOYSA-N
SMILES: O=C1N(C2=CC=CC(F)=C2)NC3=C1C(NCCCC)=NC4=CC=CC=C34
Biological Activity: PQ-69 is a potent and selective adenosine A1 receptor antagonist with inverse agonist activity. PQ-69 binds to hA1 receptor with a Ki value of 0.96 nM, is 217-fold more selective compared with hA2A receptors (Ki=208 nM) and >1,000-fold selectivity over hA3 receptor (Ki >100 μM). PQ-69 can be used for the research of renal dysfunction[1].
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PQ-69 | PQ-69 is a potent and selective adenosine A1 receptor antagonist with inverse agonist activity. PQ-69 binds to hA1 receptor with a Ki value of 0.96 nM, is 217-fold more selective compared with hA2A receptors (Ki=208 nM) and >1,000-fold selectivity over hA3 receptor (Ki >100 μM). PQ-69 can be used for the research of renal dysfunction. | |||||||||||||||||||||
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