912361-26-3
Chemical Structure
DMT003096
- CAS No.: 912361-26-3
- Formula:C54H66N4O10
- Molecular Weight:931.12
IUPAC Name: benzyl 4-([1,1'-biphenyl]-2-yl)-1-(6-((2-(butylamino)-1-(4-(2-methoxy-2-oxoethoxy)-3-(methoxycarbonyl)phenyl)-2-oxoethyl)(hexyl)amino)-6-oxohexyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
InChIKey: NSXAKOFJIUXNBS-UHFFFAOYSA-N
SMILES: O=C(OCC1=CC=CC=C1)C2=C(N(C(NC2C3=CC=CC=C3C4=CC=CC=C4)=O)CCCCCC(N(CCCCCC)C(C(NCCCC)=O)C5=CC=C(C(C(OC)=O)=C5)OCC(OC)=O)=O)C
Biological Activity: DMT003096 is an Hsp70 inhibitor that inhibits J domain (TAg)-stimulated Hsp70 ATPase activity without affecting endogenous Hsp70 ATP hydrolysis[1][2].DMT003096 inhibits breast cancer cell proliferation[1][2].DMT003096 can be used for the research of breast cancer[1][2].
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DMT003096 | DMT003096 is an Hsp70 inhibitor that inhibits J domain (TAg)-stimulated Hsp70 ATPase activity without affecting endogenous Hsp70 ATP hydrolysis.DMT003096 inhibits breast cancer cell proliferation.DMT003096 can be used for the research of breast cancer. | |||||||||||||||||||||
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References
- [1]. Wright CM, et al. Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferation. Bioorganic & medicinal chemistry. 2008 Mar 15;16(6):3291-301. [Content Brief]
- [2]. Singh MK, et al. Hsp70: A Multifunctional Chaperone in Maintaining Proteostasis and Its Implications in Human Disease. Cells. 2025 Mar 29;14(7):509.
