912444-01-0
912444-01-0
Chemical Structure
PARP-2/1-IN-2
- CAS No.: 912444-01-0
- Formula:C13H16N4O
- Molecular Weight:244.29
IUPAC Name: (S)-2-(2-methylpyrrolidin-2-yl)-1H-benzo[d]imidazole-7-carboxamide
InChIKey: JNAHVYVRKWKWKQ-ZDUSSCGKSA-N
SMILES: NC(C1=C2C(N=C([C@]3(C)CCCN3)N2)=CC=C1)=O
Biological Activity: PARP-2/1-IN-2 (Compound 4a), the enantiomer of Veliparib (HY-10129), is a potent PARP inhibitor with Kis of 2 and 5 nM against PARP-2 and PARP-1, respectively. PARP-2/1-IN-2 has an EC50 of 3 nM in a cell based assay of PARP activity[1].
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PARP-2/1-IN-2 | PARP-2/1-IN-2 (Compound 4a), the enantiomer of Veliparib (HY-10129), is a potent PARP inhibitor with Kis of 2 and 5 nM against PARP-2 and PARP-1, respectively. PARP-2/1-IN-2 has an EC50 of 3 nM in a cell based assay of PARP activity. | |||||||||||||||||||||
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