912970-79-7
912970-79-7
Chemical Structure
PRMT6-IN-2
- CAS No.: 912970-79-7
- Formula:C23H28FN3O
- Molecular Weight:381.49
IUPAC Name: 2-(4-(3-fluoro-2-(2-methoxyphenyl)-1H-indol-5-yl)piperidin-1-yl)-N-methylethan-1-amine
InChIKey: SPSRJAZORUFUOI-UHFFFAOYSA-N
SMILES: CNCCN1CCC(C2=CC3=C(NC(C4=CC=CC=C4OC)=C3F)C=C2)CC1
Biological Activity: PRMT6-IN-2 (compound 2) is a dual inhibitor of protein arginine methyltransferase PRMT6 and CARM1 with an IC50 of 30 nM. PRMT6 is abnormally expressed in many cancer cells, and PRMT6-IN-2-based derivatives have potential anticancer activity.
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PRMT6-IN-2 | PRMT6-IN-2 (compound 2) is a dual inhibitor of protein arginine methyltransferase PRMT6 and CARM1 with an IC50 of 30 nM. PRMT6 is abnormally expressed in many cancer cells, and PRMT6-IN-2-based derivatives have potential anticancer activity. | |||||||||||||||||||||
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