915365-57-0
915365-57-0
Chemical Structure
Cot inhibitor-1
- CAS No.: 915365-57-0
- Formula:C27H27Cl2FN8
- Molecular Weight:553.46
IUPAC Name: 6-(((1-(2-(azepan-1-yl)ethyl)-1H-1,2,3-triazol-4-yl)methyl)amino)-8-chloro-4-((3-chloro-4-fluorophenyl)amino)quinoline-3-carbonitrile
InChIKey: ZWFKJFUFYPOTKL-UHFFFAOYSA-N
SMILES: N#CC1=C(C2=CC(NCC3=CN(CCN4CCCCCC4)N=N3)=CC(Cl)=C2N=C1)NC5=CC=C(F)C(Cl)=C5
Biological Activity: Cot inhibitor-1 (compound 28) is a selective tumor progression loci-2 (Tpl2) kinase inhibitor with an IC50 of 28 nM. Cot inhibitor-1 shows an inhibition of TNF-alpha production in human whole blood with an IC50 of 5.7 nM[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Cot inhibitor-1 | 98.45% | Cot inhibitor-1 (compound 28) is a selective tumor progression loci-2 (Tpl2) kinase inhibitor with an IC50 of 28 nM. Cot inhibitor-1 shows an inhibition of TNF-alpha production in human whole blood with an IC50 of 5.7 nM. | ||||||||||||||||||||
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