915942-25-5
915942-25-5
Chemical Structure
HKI-357 dimaleate
- CAS No.: 915942-25-5
- Formula:C39H37ClFN5O11
- Molecular Weight:806.19
InChIKey: XQJVNEZMRMUPTL-ZMKZOGGKSA-N
SMILES: OC(/C=C\C(O)=O)=O.CCOC(C(NC(/C=C/CN(C)C)=O)=C1)=CC2=C1C(NC3=CC(Cl)=C(C=C3)OCC4=CC(F)=CC=C4)=C(C#N)C=N2.OC(/C=C\C(O)=O)=O
Biological Activity: HKI-357 dimaleate is an irreversible dual inhibitor of EGFR and ERBB2 with IC50s of 34 nM and 33 nM, respectively. HKI-357 dimaleate suppresses EGFR autophosphorylation (at Y1068), and AKT and MAPK phosphorylation[1].
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HKI-357 dimaleate | HKI-357 dimaleate is an irreversible dual inhibitor of EGFR and ERBB2 with IC50s of 34 nM and 33 nM, respectively. HKI-357 dimaleate suppresses EGFR autophosphorylation (at Y1068), and AKT and MAPK phosphorylation. | |||||||||||||||||||||
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