916046-55-4
916046-55-4
Chemical Structure
CRTh2 antagonist 4
- CAS No.: 916046-55-4
- Formula:C20H14ClFN2O5
- Molecular Weight:416.79
IUPAC Name: 2-(5-chloro-1'-(2-fluorobenzyl)-2,2',5'-trioxospiro[indoline-3,3'-pyrrolidin]-1-yl)acetic acid
InChIKey: SKLDVYDFQCXARY-UHFFFAOYSA-N
SMILES: O=C(O)CN1C(C2(C(N(CC3=CC=CC=C3F)C(C2)=O)=O)C4=C1C=CC(Cl)=C4)=O
Biological Activity: CRTh2 antagonist 4 (compound 58) is an inhibitor (IC50: 212 nM) of TH2 lymphocyte (CRTH2 or DP2) receptor with high binding affinity (Ki= 37 nM). CRTh2 antagonist 4 can be used in the study of severe allergic diseases[1].
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CRTh2 antagonist 4 | CRTh2 antagonist 4 (compound 58) is an inhibitor (IC50: 212 nM) of TH2 lymphocyte (CRTH2 or DP2) receptor with high binding affinity (Ki= 37 nM). CRTh2 antagonist 4 can be used in the study of severe allergic diseases. | |||||||||||||||||||||
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