916219-50-6
Chemical Structure
AM-3189
- CAS No.: 916219-50-6
- Formula:C27H25ClN2O3
- Molecular Weight:460.95
IUPAC Name: (S)-3-(4-((4'-chloro-2'-methyl-[1,1'-biphenyl]-3-yl)methoxy)phenyl)-3-(1-methyl-1H-imidazol-2-yl)propanoic acid
InChIKey: GFFXCPIMXLSUGF-VWLOTQADSA-N
SMILES: OC(C[C@H](C1=NC=CN1C)C2=CC=C(C=C2)OCC3=CC(C4=C(C=C(C=C4)Cl)C)=CC=C3)=O
Biological Activity: AM-3189 is an orally active and selective GPR40 agonist with EC50 values in buffer solution and in 100% human serum of 33 nM and 10 μM respectively. AM-3189 shows no significant activity on GPR41 and GPR43, and no agonistic activity on PPAR-α, -δ, and -γ. AM-3189 enhances glucose-stimulated insulin secretion by activating GPR40 on pancreatic β cells. AM-3189 has extremely low penetration into the central nervous system and significantly reduces blood glucose levels in two humanized GPR40 mouse models. AM-3189 can be used for the study of type 2 diabetes[1].
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AM-3189 | AM-3189 is an orally active and selective GPR40 agonist with EC50 values in buffer solution and in 100% human serum of 33 nM and 10 μM respectively. AM-3189 shows no significant activity on GPR41 and GPR43, and no agonistic activity on PPAR-α, -δ, and -γ. AM-3189 enhances glucose-stimulated insulin secretion by activating GPR40 on pancreatic β cells. AM-3189 has extremely low penetration into the central nervous system and significantly reduces blood glucose levels in two humanized GPR40 mouse models. AM-3189 can be used for the study of type 2 diabetes. | |||||||||||||||||||||
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