916338-03-9
916338-03-9
Chemical Structure
SSTR5 antagonist 4
- CAS No.: 916338-03-9
- Formula:C29H34FN3O3
- Molecular Weight:491.61
IUPAC Name: N-(1-((2,6-diethoxy-4'-fluoro-[1,1'-biphenyl]-4-yl)methyl)piperidin-4-yl)-5-methylnicotinamide
InChIKey: XQGOSGUJZCQEOJ-UHFFFAOYSA-N
SMILES: O=C(NC1CCN(CC2=CC(OCC)=C(C(OCC)=C2)C=3C=CC(F)=CC3)CC1)C4=CN=CC(=C4)C
Biological Activity: SSTR5 antagonist 4 (compound 1) is a potent, selective and orally active somatostatin subtype 5 (SSTR5) antagonist (hSSTR5 IC50 = 1.3 nM, mSSTR5 IC50 = 1.0 nM). SSTR5 antagonist 4 shows efficacy in mouse oral glucose tolerance test (OGTT) in high fat diet (HFD)-mice. SSTR5 antagonist 4 can be used for type 2 diabetes research[1].
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SSTR5 antagonist 4 | SSTR5 antagonist 4 (compound 1) is a potent, selective and orally active somatostatin subtype 5 (SSTR5) antagonist (hSSTR5 IC50 = 1.3 nM, mSSTR5 IC50 = 1.0 nM). SSTR5 antagonist 4 shows efficacy in mouse oral glucose tolerance test (OGTT) in high fat diet (HFD)-mice. SSTR5 antagonist 4 can be used for type 2 diabetes research. | |||||||||||||||||||||
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