91776-47-5
Chemical Structure
Fibrostatin C
Synonym(s): P-23924C
- CAS No.: 91776-47-5
- Formula:C18H19NO8S
- Molecular Weight:409.41
IUPAC Name: N-acetyl-S-((1-hydroxy-3,6-dimethoxy-5,8-dioxo-5,8-dihydronaphthalen-2-yl)methyl)-L-cysteine
InChIKey: PBMJDDQAEYEYKK-NSHDSACASA-N
SMILES: O=C([C@@H](NC(C)=O)CSCC(C(O)=C1C2=O)=C(C=C1C(C(OC)=C2)=O)OC)O
Biological Activity: Fibrostatin C (P-23924C) is an orally active prolyl hydroxylase inhibitor that also inhibits collagen biosynthesis. Fibrostatin C also increases the number of cytoplasmic granules immunoreactive with antibodies to collagen I or III. Fibrostatin C inhibits the secretion of type I collagen in Tenon's capsule fibroblasts. Fibrostatin C is promising for research of the wound fibrotic response in the wound of glaucoma filtering surgery[1][2].
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Fibrostatin C | Fibrostatin C (P-23924C) is an orally active prolyl hydroxylase inhibitor that also inhibits collagen biosynthesis. Fibrostatin C also increases the number of cytoplasmic granules immunoreactive with antibodies to collagen I or III. Fibrostatin C inhibits the secretion of type I collagen in Tenon's capsule fibroblasts. Fibrostatin C is promising for research of the wound fibrotic response in the wound of glaucoma filtering surgery. | |||||||||||||||||||||
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References
- [1]. Ishimaru T, et al. Inhibition of prolyl hydroxylase activity and collagen biosynthesis by fibrostatin C, a novel inhibitor produced by Streptomyces catenulae subsp. griseospora No. 23924. J Antibiot (Tokyo). 1988 Nov;41(11):1668-74. [Content Brief]
- [2]. Saika S, et al. Effect of fibrostatin C, an inhibitor of prolyl 4-hydroxylase, on collagen secretion by human Tenon's capsule fibroblasts in vitro. Graefes Arch Clin Exp Ophthalmol. 1996 Aug;234 Suppl 1:S214-22. [Content Brief]
