919109-76-5
Chemical Structure
MK 1256
- CAS No.: 919109-76-5
- Formula:C23H23Cl2F3N4O3S
- Molecular Weight:563.42
IUPAC Name: (1R,2R)-5,5-dichloro-N-(1-cyanocyclopropyl)-2-(4-(4-(methylsulfonyl)phenyl)-1-(2,2,2-trifluoroethyl)-1H-pyrazol-3-yl)cyclohexane-1-carboxamide
InChIKey: DSHIORGRZXPVSN-IAGOWNOFSA-N
SMILES: O=C([C@H]1[C@H](C2=NN(CC(F)(F)F)C=C2C3=CC=C(S(=O)(C)=O)C=C3)CCC(Cl)(Cl)C1)NC4(C#N)CC4
Biological Activity: MK 1256 is a highly selective and orally active inhibitor of tissue protease K (Cat K) with an IC50 of 0.62 nM. MK 1256 shows extremely high selectivity towards other tissue proteases (all > 1100 times), with only a slightly lower selectivity for tissue protease F (Cat F) (110 times). MK 1256 exhibits strong anti-bone resorption activity in the osteoporosis model of rhesus monkeys with ovariectomy. MK 1256 can be used for research on osteoporosis[1].
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MK 1256 | MK 1256 is a highly selective and orally active inhibitor of tissue protease K (Cat K) with an IC50 of 0.62 nM. MK 1256 shows extremely high selectivity towards other tissue proteases (all > 1100 times), with only a slightly lower selectivity for tissue protease F (Cat F) (110 times). MK 1256 exhibits strong anti-bone resorption activity in the osteoporosis model of rhesus monkeys with ovariectomy. MK 1256 can be used for research on osteoporosis. | |||||||||||||||||||||
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