91921-56-1
Chemical Structure
Insulin B (20-30)
- CAS No.: 91921-56-1
- Formula:C60H85N15O16
- Molecular Weight:1272.43
IUPAC Name: (2R,3S,6S,9S,12S,18S,21S)-3-((S)-2-(((S)-6-amino-1-(((S)-1-carboxyethyl)amino)-1-oxohexan-2-yl)carbamoyl)pyrrolidine-1-carbonyl)-21-(2-aminoacetamido)-9,12-dibenzyl-18-(3-guanidinopropyl)-2-hydroxy-6-(4-hydroxybenzyl)-5,8,11,14,17,20-hexaoxo-4,7,10,13,16,19-hexaazatetracosan-24-oic acid
InChIKey: MKLPMLKAAHFYJO-AORDDHPWSA-N
SMILES: C([C@@H](NC([C@H](CC1=CC=C(O)C=C1)NC([C@H](CC2=CC=CC=C2)NC([C@H](CC3=CC=CC=C3)NC(CNC([C@@H](NC([C@@H](NC(CN)=O)CCC(O)=O)=O)CCCNC(=N)N)=O)=O)=O)=O)=O)[C@@H](C)O)(=O)N4[C@H](C(N[C@H](C(N[C@H](C(O)=O)C)=O)CCCCN)=O)CCC4
Biological Activity: Insulin B (20-30) is the C-terminal undecapeptide fragment of the Insulin B chain. Insulin stimulates tissue glucose uptake, inhibits fatty acid release from adipose tissue, suppresses hepatic ketogenesis, and promotes the deposition of fat and glycogen[1][2].
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Insulin B (20-30) | Insulin B (20-30) is the C-terminal undecapeptide fragment of the Insulin B chain. Insulin stimulates tissue glucose uptake, inhibits fatty acid release from adipose tissue, suppresses hepatic ketogenesis, and promotes the deposition of fat and glycogen. | |||||||||||||||||||||
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References
- [1]. Hemmasi B, et al. Synthesis of the C-terminal undeca- and protected docosapeptide of bovine insulin B-chain. Hoppe-Seyler's Zeitschrift fur physiologische Chemie. 1984 Apr;365(4):485-92.
- [2]. Ludwig DS, et al. The Carbohydrate-Insulin Model of Obesity: Beyond "Calories In, Calories Out". JAMA Intern Med. 2018 Aug 1;178(8):1098-1103.
