919279-04-2
Chemical Structure
VEGFR/PDGFR-IN-2
- CAS No.: 919279-04-2
- Formula:C21H15F4N5O2
- Molecular Weight:445.38
IUPAC Name: 1-(2-fluoro-4-((5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea
InChIKey: TWOLOZGQZKJZKJ-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=CC(=C1)C(F)(F)F)NC2=CC=C(OC3=NC=NC=4C=CN(C34)C)C=C2F
Biological Activity: VEGFR/PDGFR-IN-2 is a VEGFR1/2/3, PDGFRα/β, and Tie-2 tyrosine kinase inhibitor. VEGFR/PDGFR-IN-2 inhibits endothelial tube formation and endothelial migration by blocking VEGF-induced receptor phosphorylation and PDGF-BB signaling, reduces tumor microvessel density, pericyte recruitment, and tumor interstitial fluid pressure, and enhances the antitumor activity of CPT-11. VEGFR/PDGFR-IN-2 can be used for research on solid tumors[1].
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VEGFR/PDGFR-IN-2 | VEGFR/PDGFR-IN-2 is a VEGFR1/2/3, PDGFRα/β, and Tie-2 tyrosine kinase inhibitor. VEGFR/PDGFR-IN-2 inhibits endothelial tube formation and endothelial migration by blocking VEGF-induced receptor phosphorylation and PDGF-BB signaling, reduces tumor microvessel density, pericyte recruitment, and tumor interstitial fluid pressure, and enhances the antitumor activity of CPT-11. VEGFR/PDGFR-IN-2 can be used for research on solid tumors. | |||||||||||||||||||||
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