91996-54-2
91996-54-2
Chemical Structure
Trichlormethiazide sodium
- CAS No.: 91996-54-2
- Formula:C8H8Cl3N3NaO4S2
- Molecular Weight:403.65
IUPAC Name: 6-chloro-3-(dichloromethyl)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide, sodium salt
InChIKey: WGWZPLPNHCVTNO-UHFFFAOYSA-N
SMILES: O=S(C1=C(Cl)C=C(C2=C1)NC(C(Cl)Cl)NS2(=O)=O)(N)=O.[Na]
Biological Activity: Trichlormethiazide sodium is an orally active thiazide diuretic, with antihypertensive effect. Trichlormethiazide sodium increases urine volume (UV), Na and K excretion and tends to improve the depressed creatinine clearance (CCRE) in acute renal failure rats model[1][2].
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Trichlormethiazide sodium | Trichlormethiazide sodium is an orally active thiazide diuretic, with antihypertensive effect. Trichlormethiazide sodium increases urine volume (UV), Na and K excretion and tends to improve the depressed creatinine clearance (CCRE) in acute renal failure rats model. | |||||||||||||||||||||
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References
- [1]. K Yao, et al. Diuretic effects of KW-3902, a novel adenosine A1-receptor antagonist, in various models of acute renal failure in rats. Jpn J Pharmacol. 1994 Apr;64(4):281-8. [Content Brief]
- [2]. J R Ballew, et al. Characterization of the antihypertensive effect of a thiazide diuretic in angiotensin II-induced hypertension. J Hypertens. 2001 Sep;19(9):1601-6. [Content Brief]
