920707-33-1
920707-33-1
Chemical Structure
BRI-12349
- CAS No.: 920707-33-1
- Formula:C17H13N5O3S2
- Molecular Weight:399.45
InChIKey: VFMKWFVPFPOFNZ-UHFFFAOYSA-N
SMILES: O=C(C1=C(NC(CSC2=NN=C(C3=CNC4=C3C=CC=C4)O2)=O)SC=C1)N
Biological Activity: BRI-12349 (Compound 50) is a dual antagonist of CysLT1R/CysLT2R with Ki values of 1.03 and 6.46 μM. BRI-12349 can inhibit the generation of IP1 induced by LTD4 (the main ligand of CysLTs). BRI-12349 can be used for the research of immunology and inflammation, such as asthma[1].
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BRI-12349 | BRI-12349 (Compound 50) is a dual antagonist of CysLT1R/CysLT2R with Ki values of 1.03 and 6.46 μM. BRI-12349 can inhibit the generation of IP1 induced by LTD4 (the main ligand of CysLTs). BRI-12349 can be used for the research of immunology and inflammation, such as asthma. | |||||||||||||||||||||
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