920836-30-2
Chemical Structure
ICB-7
- CAS No.: 920836-30-2
- Formula:C22H21ClN4O2S
- Molecular Weight:440.95
InChIKey: MOQWNAMAFUPTFR-UHFFFAOYSA-N
SMILES: COC1=C(C=C(C=C1)Cl)NC(CN(CC2=C(N=C3SC=CN32)C4=CC=CC=C4)C)=O
Biological Activity: ICB-7 is an orally active ILT3/LILRB4 inhibitor with a Kd of 156 nM for hILT3 and a Kd of 262 nM for mouse ILT3. ICB-7 reduces SCG2-induced phosphorylation of SHP1, SHP2, and STAT3. In a co-culture model, ICB-7 restores IFN-γ and IL-2 secretion and decreases cell viability under SCG2 stimulation. In a syngeneic cancer model, ICB-7 inhibits tumor progression and reduces final tumor weight. ICB-7 can be used for research on colorectal cancer and acute myeloid leukemia[1].
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ICB-7 | ICB-7 is an orally active ILT3/LILRB4 inhibitor with a Kd of 156 nM for hILT3 and a Kd of 262 nM for mouse ILT3. ICB-7 reduces SCG2-induced phosphorylation of SHP1, SHP2, and STAT3. In a co-culture model, ICB-7 restores IFN-γ and IL-2 secretion and decreases cell viability under SCG2 stimulation. In a syngeneic cancer model, ICB-7 inhibits tumor progression and reduces final tumor weight. ICB-7 can be used for research on colorectal cancer and acute myeloid leukemia. | |||||||||||||||||||||
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