921-62-0
921-62-0
Chemical Structure
6-Phosphogluconic acid
- CAS No.: 921-62-0
- Formula:C6H13O10P
- Molecular Weight:276.14
IUPAC Name: (2R,3S,4R,5R)-2,3,4,5-tetrahydroxy-6-(phosphonooxy)hexanoic acid
InChIKey: BIRSGZKFKXLSJQ-SQOUGZDYSA-N
SMILES: OC([C@H](O)[C@@H](O)[C@H](O)[C@H](O)COP(O)(O)=O)=O
Biological Activity: 6-Phosphogluconic acid is a potent and competitive phosphoglucose isomerase (PGI) inhibitor with Kis of 48 μM for glucose 6-phosphate and 42 μM for fructose 6-phosphate. 6-Phosphogluconic acid is an endogenous metabolite[1][2].
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6-Phosphogluconic acid | 6-Phosphogluconic acid is a potent and competitive phosphoglucose isomerase (PGI) inhibitor with Kis of 48 μM for glucose 6-phosphate and 42 μM for fructose 6-phosphate. 6-Phosphogluconic acid is an endogenous metabolite. | |||||||||||||||||||||
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References
- [1]. Gaitonde MK, et al. Effect of 6-phosphogluconate on phosphoglucose isomerase in rat brain in vitro and in vivo. J Neurochem. 1989 May;52(5):1348-52. [Content Brief]
- [2]. Hitosugi T, et al. Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell. 2012 Nov 13;22(5):585-600. [Content Brief]
