92407-90-4
Chemical Structure
Oncrasin-72
Synonym(s): NSC-743380
- CAS No.: 92407-90-4
- Formula:C16H14ClNO
- Molecular Weight:271.74
IUPAC Name: (1-(3-chlorobenzyl)-1H-indol-3-yl)methanol
InChIKey: LPIARNOLFFSUSO-UHFFFAOYSA-N
SMILES: ClC1=CC=CC(CN2C=C(CO)C3=C2C=CC=C3)=C1
Biological Activity: Oncrasin-72 (NSC-743380) is an RNA polymerase II inhibitor with activity in inhibiting growth and inducing cell death in human cancer cells. Oncrasin-72 exhibits antitumor activity through JNK activation and STAT3 inhibition. Analytical method development and validation for Oncrasin-72 is essential for quantifying its concentration in biological fluids for pharmacokinetic studies. This method was able to successfully quantify Oncrasin-72 in different dose groups when applied in rat plasma[1].
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Oncrasin-72 | 97.61% | Oncrasin-72 (NSC-743380) is an RNA polymerase II inhibitor with activity in inhibiting growth and inducing cell death in human cancer cells. Oncrasin-72 exhibits antitumor activity through JNK activation and STAT3 inhibition. Analytical method development and validation for Oncrasin-72 is essential for quantifying its concentration in biological fluids for pharmacokinetic studies. This method was able to successfully quantify Oncrasin-72 in different dose groups when applied in rat plasma. | ||||||||||||||||||||
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