92454-60-9
Chemical Structure
FK 409
- CAS No.: 92454-60-9
- Formula:C8H13N3O4
- Molecular Weight:215.21
IUPAC Name: (2Z,3E)-4-ethyl-2-(hydroxyimino)-5-nitrohex-3-enamide
InChIKey: MZAGXDHQGXUDDX-JSRXJHBZSA-N
SMILES: CC([N+]([O-])=O)/C(CC)=C/C(C(N)=O)=N/O
Biological Activity: FK 409 is a NO donor that can penetrate cell membranes. FK 409 has a vasodilatory effect on bovine retinal arteries. FK 409 alleviates acute-phase inflammation, induces HSP, and mitigates liver transplantation injury in a rat model of orthotopic liver transplantation. FK 409 can be used in research on cardiovascular diseases and liver transplant rejection and inflammatory immune system disorders[1][2].
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FK 409 | FK 409 is a NO donor that can penetrate cell membranes. FK 409 has a vasodilatory effect on bovine retinal arteries. FK 409 alleviates acute-phase inflammation, induces HSP, and mitigates liver transplantation injury in a rat model of orthotopic liver transplantation. FK 409 can be used in research on cardiovascular diseases and liver transplant rejection and inflammatory immune system disorders. | |||||||||||||||||||||
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References
- [1]. Man K, et al. FK 409 ameliorates small-for-size liver graft injury by attenuation of portal hypertension and down-regulation of Egr-1 pathway. Ann Surg. 2004 Jul;240(1):159-68. [Content Brief]
- [2]. Sugimoto K, et al. [Vasodilatory action of FK 409 on bovine retinal arteries--analysis by a microvessel perfusion system]. Nippon Ganka Gakkai Zasshi. 2002 Jun;106(6):338-42. Japanese. [Content Brief]
