926277-68-1
Chemical Structure
Modimelanotide
Synonym(s): ABT-719; AP-214
- CAS No.: 926277-68-1
- Formula:C113H181N33O25S
- Molecular Weight:2433.92
IUPAC Name: (4S,7S,10S,13S,16S,19S,22S,25S,28S,31S,34S)-34-(((2S,5S,8S,11S,17S)-11-((1H-indol-3-yl)methyl)-21-amino-17-((S)-2-(((S)-1-amino-3-methyl-1-oxobutan-2-yl)carbamoyl)pyrrolidine-1-carbonyl)-5-benzyl-8-(3-guanidinopropyl)-1-(1H-imidazol-5-yl)-3,6,9,12,15-pentaoxo-4,7,10,13,16-pentaazahenicosan-2-yl)carbamoyl)-4,7,10,13,16,19-hexakis(4-aminobutyl)-25-(4-hydroxybenzyl)-22,28-bis(hydroxymethyl)-31-(2-(methylthio)ethyl)-2,5,8,11,14,17,20,23,26,29,32-undecaoxo-3,6,9,12,15,18,21,24,27,30,33-undecaazaheptatriacontan-37-oic acid
InChIKey: WHRVKPBBRZHWTN-MZJBPVDRSA-N
SMILES: O=C(C)N[C@@H](CCCCN)C(N[C@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@H](CCCCN)C(N[C@@H](CO)C(N[C@H](CC1=CC=C(O)C=C1)C(N[C@@H](CO)C(N[C@H](CCSC)C(N[C@@H](CCC(O)=O)C(N[C@H](CC2=CN=CN2)C(N[C@H](C(N[C@H](CCCNC(N)=N)C(N[C@@H](CC3=CNC4=C3C=CC=C4)C(NCC(N[C@@H](CCCCN)C(N5[C@H](C(N[C@@H](C(C)C)C(N)=O)=O)CCC5)=O)=O)=O)=O)=O)CC6=CC=CC=C6)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Biological Activity: Modimelanotide (ABT-719) is an α-melanocyte-stimulating hormone analog. Modimelanotide has high specific binding ability to melanocortin receptors (MCR1, 3, 4, 5). Modimelanotide possesses anti-inflammatory and organ-protective effects. Modimelanotide can be used in the research of diseases such as acute kidney injury[1][2].
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Modimelanotide | Modimelanotide (ABT-719) is an α-melanocyte-stimulating hormone analog. Modimelanotide has high specific binding ability to melanocortin receptors (MCR1, 3, 4, 5). Modimelanotide possesses anti-inflammatory and organ-protective effects. Modimelanotide can be used in the research of diseases such as acute kidney injury. | |||||||||||||||||||||
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References
- [1]. Ruiz J. Transferable Mechanisms of Quinolone Resistance from 1998 Onward. Clin Microbiol Rev. 2019 Aug 14;32(4):e00007-19. [Content Brief]
- [2]. McCullough PA, et al. ABT-719 for the Prevention of Acute Kidney Injury in Patients Undergoing High-Risk Cardiac Surgery: A Randomized Phase 2b Clinical Trial. J Am Heart Assoc. 2016 Aug 20;5(8):e003549. [Content Brief]
