926319-75-7
Chemical Structure
Protein kinase inhibitor 8
- CAS No.: 926319-75-7
- Formula:C21H37N7O3
- Molecular Weight:435.56
IUPAC Name: tert-butyl (6-((2-((2-hydroxyethyl)amino)-9-isopropyl-9H-purin-6-yl)amino)hexyl)carbamate
InChIKey: OXQIKGQQLYDQBM-UHFFFAOYSA-N
SMILES: O=C(OC(C)(C)C)NCCCCCCNC1=C2N=CN(C(C)C)C2=NC(NCCO)=N1
Biological Activity: Protein kinase inhibitor 8 (Compound CK59) is a calmodulin-dependent protein kinase II (CaMKII) inhibitor. By inhibiting the activity of CaMKII, Protein kinase inhibitor 8 can attenuate the cytotoxicity induced by perfluorooctane sulfonic acid (PFOS) and alleviate the downregulation of GLT-1 expression caused by PFOS, thereby reducing neuronal damage. Protein kinase inhibitor 8 may be useful in research related to neurodegenerative diseases[1][2].
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Protein kinase inhibitor 8 | Protein kinase inhibitor 8 (Compound CK59) is a calmodulin-dependent protein kinase II (CaMKII) inhibitor. By inhibiting the activity of CaMKII, Protein kinase inhibitor 8 can attenuate the cytotoxicity induced by perfluorooctane sulfonic acid (PFOS) and alleviate the downregulation of GLT-1 expression caused by PFOS, thereby reducing neuronal damage. Protein kinase inhibitor 8 may be useful in research related to neurodegenerative diseases. | |||||||||||||||||||||
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References
- [1]. Yang J, et al. PFOS Elicits Cytotoxicity in Neuron Through Astrocyte-Derived CaMKII-DLG1 Signaling In Vitro Rat Hippocampal Model. Neurochem Res. 2024 May;49(5):1226-1238. [Content Brief]
- [2]. Scheiter M, et al. Protein Kinase Inhibitors CK59 and CID755673 Alter Primary Human NK Cell Effector Functions. Front Immunol. 2013 Mar 18;4:66. [Content Brief]
