926493-93-8
Chemical Structure
F3288-0031
- CAS No.: 926493-93-8
- Formula:C24H32N2O3
- Molecular Weight:396.52
InChIKey: GXTSPQLTLPKKOH-XVNBXDOJSA-N
SMILES: C/C=C/C1=CC(OC)=C(C=C1)OCC(CN2CCN(CC2)CC3=CC=CC=C3)O
Biological Activity: F3288-0031 is a brain-penetrant norepinephrine transporter (NET) allosteric inhibitor with inhibitory rates of 73.5% at 20 μM. F3288-0031 binds within the inner vestibule of NET, stabilizing the inward-open state and has a preferential NET/SERT inhibition with pIC50 = 5.9. F3288-0031 shows no detectable off-target functional activity in vitro. F3288-0031 demonstrates robust antidepressant-like efficacy in vivo without confounding locomotor effects, F3288-0031 can be used for depressive disorder and related neuropsychiatric conditions[1].
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F3288-0031 | F3288-0031 is a brain-penetrant norepinephrine transporter (NET) allosteric inhibitor with inhibitory rates of 73.5% at 20 μM. F3288-0031 binds within the inner vestibule of NET, stabilizing the inward-open state and has a preferential NET/SERT inhibition with pIC50 = 5.9. F3288-0031 shows no detectable off-target functional activity in vitro. F3288-0031 demonstrates robust antidepressant-like efficacy in vivo without confounding locomotor effects, F3288-0031 can be used for depressive disorder and related neuropsychiatric conditions. | |||||||||||||||||||||
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