928205-59-8
Chemical Structure
cis-THSG
- CAS No.: 928205-59-8
- Formula:C20H22O9
- Molecular Weight:406.38
IUPAC Name: (2S,3R,4S,5S,6R)-2-(2,4-dihydroxy-6-((Z)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
InChIKey: JAYVHSBYKLLDJC-ZPBLDHPVSA-N
SMILES: O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@@H]1OC2=C(/C=C\C3=CC=C(O)C=C3)C=C(O)C=C2O
Biological Activity: cis-THSG is a selective and orally active DNA topoisomerase II inhibitor with no activity against DNA topoisomerase I. cis-THSG suppresses transcription of PEPCK. cis-THSG reduces blood glucose levels, ameliorates glucose intolerance, and alleviates insulin resistance in high fat diet-induced diabetic male CF-1 mice. cis-THSG can be used for the research of type 2 diabetes mellitus[1][2].
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cis-THSG | cis-THSG is a selective and orally active DNA topoisomerase II inhibitor with no activity against DNA topoisomerase I. cis-THSG suppresses transcription of PEPCK. cis-THSG reduces blood glucose levels, ameliorates glucose intolerance, and alleviates insulin resistance in high fat diet-induced diabetic male CF-1 mice. cis-THSG can be used for the research of type 2 diabetes mellitus. | |||||||||||||||||||||
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References
- [1]. Xu ML, et al. A new stilbene glucoside from the roots of Polygonum multiflorum Thunb. Arch Pharm Res. 2006;29(11):946-951. [Content Brief]
- [2]. Tang W, et al. Anti-diabetic activities of cis- and trans-2,3,5,4'-tetrahydroxystilbene 2-O-β-glucopyranoside from Polygonum multiflorum. Mol Nutr Food Res. 2017 Aug;61(8). [Content Brief]
