929016-98-8
929016-98-8
Chemical Structure
Pracinostat dihydrochloride
- CAS No.: 929016-98-8
- Formula:C20H32Cl2N4O2
- Molecular Weight:431.40
IUPAC Name: (E)-3-(2-butyl-1-(2-(diethylamino)ethyl)-1H-benzo[d]imidazol-5-yl)-N-hydroxyacrylamide dihydrochloride
InChIKey: CHLPUMOYKYJFFH-PFNYCKIMSA-N
SMILES: CCN(CCN1C2=CC=C(C=C2N=C1CCCC)/C=C/C(NO)=O)CC.Cl.Cl
Biological Activity: Pracinostat dihydrochloride is a potent histone deacetylase (HDAC) inhibitor, with IC50s of 40-140 nM, used for cancer research. Pracinostat dihydrochloride also inhibits metallo-β-lactamase domain-containing protein 2 (MBLAC2) hydrolase activity with an EC50 below 10 nM[1][4].
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Pracinostat dihydrochloride | Pracinostat dihydrochloride is a potent histone deacetylase (HDAC) inhibitor, with IC50s of 40-140 nM, used for cancer research. Pracinostat dihydrochloride also inhibits metallo-β-lactamase domain-containing protein 2 (MBLAC2) hydrolase activity with an EC50 below 10 nM. | |||||||||||||||||||||
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References
- [1]. Novotny-Diermayr V, et al. SB939, a novel potent and orally active histone deacetylase inhibitor with high tumor exposure and efficacy in mouse models of colorectal cancer. Mol Cancer Ther. 2010 Mar;9(3):642-52. [Content Brief]
- [4]. Lechner S, et al. Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target. Nat Chem Biol. 2022 Aug;18(8):812-820. [Content Brief]
